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The Fentanyl Patch Fentanyl was first made available for palliative use in the mid-1990s in the form of a patch. Over the following ten years, several forms of the drug were reabsorbed via the skin within the mouth, including a lollipop, dissolving pills, and sublingual spray. Fentanyl was the most often used synthetic opioid in medicine as of 2012. Around the world, 1700 kilos were utilized in 2013.